Abstract Background Exercise during postnatal development plays a key role in determining adult bone mass and reducing the risk of fracture and osteoporosis later in life.However, the relationship between mechanically-induced osteogenesis and age is unclear.Elevated levels of estrogen during puberty may inhibit periosteal bone formation.
Thus, magnitudes of mechanically-induced osteogenesis may be vary SCALP TONIC with pubertal state.Methods The present study uses a murine model to examine age-related changes in bone formation at the femoral midshaft with voluntary exercise.Pre- to peripubertal mice aged 3 weeks and peri- to postpubertal mice aged 7 8 Piece Full Bookcase Bed Bedroom Package weeks were randomly divided into sedentary and exercised groups and subjected to histomorphometric comparison after 4 weeks of treatment.
Results Results of the experiment indicate that exercise significantly increased osteogenesis on the periosteal and endocortical surface of the mice in the older age group (P P Conclusion These findings suggest that the amount and location of mechanically-induced osteogenesis differs by age during skeletal development.Late adolescence may be the optimal time to accrue bone mass and maximize bone strength.