Abstract Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are closely related nuclear receptors with overlapping regulatory functions in xenobiotic clearance but distinct roles in endobiotic metabolism.Car activation has been demonstrated to ameliorate hypercholesterolemia by regulating cholesterol metabolism and bile acid elimi
An Ensemble Machine Learning Model for Early Prediction of Vancomycin-Induced Acute Kidney Injury in ICU Patients
Introduction: Acute Kidney Injury (AKI) is a severe complication of vancomycin treatment due to its nephrotoxic effects.However, research on predicting AKI in this high-risk group remains limited.This study Bangers presents a stacking ensemble machine learning model designed to predict the onset of AKI in this patient population.Methods: Leveraging
Mechanically-induced osteogenesis in the cortical bone of pre- to peripubertal stage and peri- to postpubertal stage mice
Abstract Background Exercise during postnatal development plays a key role in determining adult bone mass and reducing the risk of fracture and osteoporosis later in life.However, the relationship between mechanically-induced osteogenesis and age is unclear.Elevated levels of estrogen during puberty may inhibit periosteal bone formation.Thus, magni
Low-Intensity Focused Ultrasound Stimulation on Fingertip Can Evoke Fine Tactile Sensations and Different Local Hemodynamic Responses
Low-intensity focused ultrasound stimulation (LIFUS) has been proved effective in eliciting vibrotactile in addition to warm, cold and nociceptive pain when applied to human peripheral endings.However, Heated Gloves if it can evoke fine tactile sensations has been rarely investigated by far despite the importance of fine tactile feedback in motor c